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Endothelial cells (ECs) covering the inner surface of the vascular wall can generate, activate, and release various vasoactive substances and regulate cardiovascular function, including nitric oxide (NO), prostacyclin (PGI2), endothelin-1 (ET-1), and endothelium-derived contracting factors (EDCF)

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This cohort study compares treatment-associated weight loss and rates of gastrointestinal adverse events among adults with overweight or obesity receiving tirzepatide or semaglutide labeled for type 2 diabetes in a clinical setting