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Whilst these medicines offer significant therapeutic benefits, some patients report experiencing an unpleasant taste in their mouth during treatmentoften described as metallic, bitter, or simply 'off'

[2] [3] Recognizing gastroparesis in patients taking GLP-1 medications requires careful clinical assessment, as symptoms overlap considerably with common, transient GLP-1 side effects

While these antiinflammatory effects have not been attributed to GLP-1 action in specific organs or cell types, the kidney GLP-1R has been localized primarily to vascular smooth muscle cells within renal arteries and arterioles using either 125 I-labeled exendin-4, a validated antiGLP-1R antibody, or in situ hybridization (71, 72)

Oral semaglutide is more likely to cause side effects such as nausea, vomiting, and abdominal pain