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So some people's HS got better even without the weight loss, which like we were saying, speaks to this anti-inflammatory effect that the medications are probably having

Side effects are often temporary and may improve as the body adjusts to the medication

IL-1 is known to disrupt long-term potentiation and synaptic transmission [34] while TNF- alters postsynaptic AMPA receptor regulation [35], thereby impairing synaptic homeostasis
