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A dual GLP-1-estrogen conjugate (GE) designed to selectively deliver estrogen to GLP-1R + cells induced substantial weight loss in mice without evidence of systemic estrogenic effects, as assessed by uterine weight and growth of estrogen-dependent breast cancer xenografts (Finan et al., 2012)

This hormone is released by the gut in response to eating and is engineered to leverage the hormones profound effect on appetite regulation and satiety, making it a powerful tool for achieving substantial weight loss

Other potential side effects to be aware of include injection site reactions (redness, itching, or swelling), headache, fatigue, and dizziness