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Thats a subtle but important shift in how we understand these medications
Experimentally, one-month regimen of exenatide in rats increased the length and weight of the small intestine by 9% and 31%, respectively 6 , consistent with our own observations that the rats had an average increase of 43% in the small intestine length after 3-month treatment of polyethylene glycol (PEG)-exenatide (data not shown)
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The protein DPP-4 is localized to a small pocket known as the catalytic pocket, which has serine at position 630
