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Nevertheless, GLP-1 presented a rather ephemeral circulatory half-life, lasting a mere 12 min, due to the rapid enzymatic degradation by dipeptidyl peptidase IV (DPP-4), which markedly limits its biological efficacy [3,4,5]

Your genes can impact how you respond to a GLP-1 In a study published in Genome Medicine , researchers found that about 10 percent of people carry certain variants of what's known as the PAM gene, and those individuals had a weaker blood sugar response to GLP-1based drugs compared to non-carriers

Wegovy semaglutide tablets work by reducing appetite and food intake overall, which means they can be effective across a broader range of dietary patterns