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Your dose should increase gradually based on your response and tolerance
There is a lot of evidence that GLP-1s do an effective job at managing diabetes and that is PHENOMENAL I cannot stress that enough

Whole-cell currents at 70 mV triggered by 1 mm glycine were also blocked 98 2% ( n = 4) by 10 m strychnine, and currents induced by 1 mm GABA were inhibited 91 3% ( n = 3) by 100 m picrotoxin

The 0.25 mg starting dose is mild and often causes minimal side effects, which is why it's used to establish tolerance
