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This can have emotional and social consequences, and people who have facial changes due to semaglutide use might: Experience body shame, become obsessed with appearance, and feel unattractive

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[Accessed 09/09/2025] Once-weekly semaglutide 72 mg in adults with obesity (STEP UP): a randomised, controlled, phase 3b trial

However, at pharmacological concentrations achieved with therapeutic GLP-1 receptor agonists (100 pM10 nM), -arrestin-2 becomes essential for sustained signaling, specifically mediating extracellular signal-regulated kinase (ERK) activation and CREB phosphorylation that promotes pancreatic -cell survival and insulin synthesis