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Long-term metformin use is generally well-tolerated, which is why it remains a first-line diabetes medication worldwide

S5A and I), -SMA (Fig

Low concentrations of glucose or methyl--glucopyranoside stimulate L-cell electrical activity and promote GLP-1 secretion via sodium-glucose cotransporter (SGLT1)-dependent induction of small inward currents (Figure 3) [247]

(2014) 134:154e60e
