how long for semaglutide side effects to go away Effects: What Expect and When to Seek Help I lost 20 lbs, but
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Blinding in the STEP 1 to STEP 4 trials may have been compromised somewhat, however, by the fact that the primary outcome is based on a readily measurable, objective measure (weight loss) that patients can self-monitor, and by the large imbalance in GI AEs, a well-known complication of GLP-1 agonists
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This is why Phase 3 TRIUMPH protocols allow dose reduction rather than discontinuation when a participant approaches a low BMI
