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Regarding gastric emptying, injectable GLP-1RA generally produces a more pronounced and sustained delay, whereas oral semaglutide shows a modest, early-phase effect that attenuates at steady state [74]

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Although the actions of GLP-1 on the beta-cell are preserved yet modestly diminished in T2DM, the diabetic alpha-cell retains near normal responsivity to low dose GLP-1 infusion, with inhibition of glucagon secretion seen to a similar extent in diabetic vs

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