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The Phase 3 TRIUMPH program kicked off in 2022, with key results expected through 2026 and 2027

[DOI] [PMC free article] [PubMed] [Google Scholar] 117.Lpez-Ojeda W., Hurley R.A

Naunyn-Schmiedeberg's Arch Pharmacol (2018) 391(8):87581

Key pharmacological effects include: Glucose-dependent insulin secretion Enhanced pancreatic beta-cell insulin release only when blood glucose is elevated, reducing hypoglycemia risk Suppression of glucagon secretion Decreased hepatic glucose production from pancreatic alpha cells Delayed gastric emptying Slowed movement of food from the stomach to the small intestine Central appetite regulation Reduced hunger and increased satiety through hypothalamic pathways The delayed gastric emptying effect is particularly significant and represents both a therapeutic mechanism and a potential source of adverse effects