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EMPA-REG Outcomes Trial A post hoc analysis of EMPA-REG OUTCOMES data [32] evaluating the early benefits showed a significant weight reduction with empagliflozin vs

It therefore appears that circulating PYY 3-36 inhibits appetite by acting directly on the ARC via the Y 2 receptor, increasing the activity of anorexigenic POMC/-MSH neurons, whilst suppressing orexigenic NPY neurons

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