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Tufts Now: Dariush Mozaffarian : GLP-1s have captured national attention for their ability to help people achieve significant weight reduction, but successful weight loss requires more than a prescription

This structural modification enhances resistance to enzymatic degradation and supports prolonged receptor interaction under experimental conditions

Weight loss itself can indirectly reduce fatigue in some patients

Hence, in 2022, glucose-lowering efficacy and proven cardiovascular effects were important for the strong positioning of semaglutide, dulaglutide and tirzepatide in guidelines on the management of hyperglycaemia in type 2 diabetes [33], and a similar strong positioning of incretin therapy was seen in guidelines on primary care [39]