semaglutide pain in left side effects for diabetes and obesity treatment Ozempic and GLP-1 Drugs: Risk

doi: 10.3389/fsurg.2024.1449012 Received 14 June 2024 Accepted 16 October 2024 Published 01 November 2024 Volume 11 - 2024 Edited by Dragomir Dardanov, Lozenetz Hospital, Bulgaria Reviewed by Ioannis I

The complex structure of GLP-1R poses a challenge for drug development

Emerging alternatives like the Onmorlo GLP-1 patch could eliminate both the injection requirement and the strict oral dosing protocols, making GLP-1 therapy as simple as applying a patch

This initiates a cascade that leads to the activation of protein kinase A (PKA), closing of potassium channels, depolarization, and release of calcium from the endoplasmic reticulum.3 An increase of intracellular calcium levels within the cell initiates insulin expression in the nucleus, stimulates energy (ATP) production in the mitochondria, and triggers the release of insulin into the blood stream in a glucose dependent manner (image adapted from Adipogen Life Sciences).4,5 Several commercially and prescribed agents are now available for the management of obesity and type 2 diabetes