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For those using GLP-1 receptor agonists primarily for weight management , there is similarly no physiological need to wean off the medication

Role of renal sympathetic nerves in GLP-1 (glucagon-like peptide-1) receptor agonist exendin-4-mediated diuresis and natriuresis in diet-induced obese rats

The addition of tirzepatide, which delays gastric emptying, could exacerbate these symptoms
Heart rate effects during this window may not be representative of the eventual stable-state response
