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The SURMOUNT-5 trial, published in 2025 in the New England Journal of Medicine, directly compared tirzepatide with semaglutide
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Sections were placed onto positively charged histobond microscope slides and left to defrost
Mouse studies Female C57BL/6 J mice 89 weeks of age (Jackson Labs, Bar Harbor, ME) were randomized to either a control (Con, 10 kcal% fat, D12450J, Research Diets, New Brunswick, NJ) or diet-induced obesity (DIO, 60 kcal% fat, sucrose-matched to Con, D12492, Research Diets) diet for 15 weeks
