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*Table: Reported Influences on Libido with GLP-1/GIP Agonists* A 2022 study in Diabetes, Obesity and Metabolism on tirzepatide noted that quality of life measures related to physical function and self-esteem improved significantly, which often correlates with better sexual health

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Histone deacetylases (HDAC2), a member of the HDAC family, is correlated with insulin signaling components in postsynaptic glutamatergic neurons of the adult mouse hippocampus, and hyperactivity of the HDAC system (including HDAC2) may result in the suppression of the insulin signaling system and consequent disruption of synaptic plasticity in type 2 diabetes.137 GLP-1 RA has a definite effect on improving synaptic plasticity