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Investigating potential contributors such as microvascular injury, inflammatory processes, alterations in nerve metabolism, and the role of specific glycemic control strategies is crucial for unraveling the etiology of TIND

The landmark phase 2 trial published in the New England Journal of Medicine used a structured escalation from 1mg through to 12mg per week across six separate dose arms, with participants achieving up to 24.2% body weight reduction at the highest escalation

Rave K, Potocka E, Heinemann L et al (2009b) Pharmacokinetics and linear exposure of AFRESA compared with the subcutaneous injection of regular human insulin

Both formats require a board-certified physician consultation