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Description
In particular, His7 (in the N-terminus of GLP-1) has a free alpha-amino group and an imidazole side chain that are important for the GLP-1R/GLP-1 interaction18)
Thiolene click chemistry encompasses the reaction between a thiol group and an alkene group to form a thioether linkage
But lyophilization adds a processing step and requires specialized equipment
Wegovy single-dose pens should be stored refrigerated but may be kept at temperatures up to 86F (30C) for up to 28 days prior to use, then discarded after injection
