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Key contributing factors include advancing age, long-standing disease duration, and suboptimal glycemic control, as well as insulin resistance and androgen deficiencythe latter being particularly common in men with type 2 diabetes (T2D) and obesity
Two sites in TM4 have been highlighted as being key to GLP-1 activity
The underlying mechanisms for the GLP-1RA-induced heart rate increase remain unclear [9, 10]
