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However, in approximately 510% of patients, digestive side effects are severe enough to warrant dose reduction or discontinuation of treatment
Mounjaro for diabetes) demonstrated significant weight loss in the SURMOUNT-1 trial published in the New England Journal of Medicine (2022), with mean reductions of 1522% depending on dose
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Furthermore, GLP-1RAs can increase diuretic and natriuretic actions through changes in renal hemodynamics and inhibition of the sodium-hydrogen exchanger 3 in the renal proximal tubule [56]
