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The most common exclusion criteria included major depressive disorder, uncontrolled hypertension, malignant neoplasms and liver disease, with the latter for tirzepatide only

In the SURMOUNT-1 trial , participants receiving the highest dose of Tirzepatide achieved average body weight reductions of 20.9% over 72 weeks, compared to the 14.9% reduction observed with Semaglutide in the STEP-1 trial