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a Effectiveness is based on average excess weight loss (EWL) or total body weight loss (TBWL) over the indicated time period

Some GLP-1 and related medications are approved for chronic weight management in eligible adults without diabetes

A systematic review found that GLP-1 receptor agonists significantly reduced albuminuria, a marker of kidney damage, and slowed the decline in kidney function, particularly in patients with early-stage renal disease

This underscores the need for both RWE and RCTs in parallel and reinforces the need to need to run clinical trials that reflect real-world populations, a topic explored in more detail in our blog Obesity trials on trial Some health improvement seen with GLP-1 therapy may be a direct effect of weight loss, rather than unique drug effect as seen by improvements in liver and kidney health 4