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After hearing anecdotes of patients on the diabetes and obesity drugs experiencing nonarteritic anterior ischemic optic neuropathy, or NAION, researchers at Massachusetts Eye and Ear analyzed data from a registry of patients at their institution to see if there was a broad trend

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This effect is likely mediated by synergistic interactions between the endogenous cannabinoid system and the endogenous opioid system at both the spinal cord and central nervous system levels [66]