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Reference medicines with a combined value of more than USD 650 billion are expected to lose patent protection over the next decade

These include dietary interventions, orlistat, lorcaserin, phentermine/topiramate, glucagon-like peptide-1 receptor agonists, dipeptidyl peptidase-4 inhibitors, pramlintide, dapagliflozin, the duodenaljejunal bypass liner, gastric pacemakers and gastric balloons

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GLP-1s can negatively affect overall bone health, contributing to conditions like