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Description
Those who received a placebo experienced a weight loss of 2.3%, with no plateau observed
The most common adverse events are mild to moderate gastrointestinal symptoms, which may be mitigated through dietary counseling during dose escalation
Lifestyle interventions often have limited success due to complex biological factors promoting weight regain [610]
Long interested in Holst's work, in 1990 Novo Nordisk recruited his colleague Schwartz to develop small molecules able to activate the GLP receptor in the pancreas (Molteni, Chen)
