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Lab testing : Thyroid issues, low testosterone, or cortisol imbalances can all contribute to depression-like symptoms

Additionally, topiramate may affect genes related to neuropeptide Y, which can influence the body's weight regulation system

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The immunopathogenesis is driven by a predominance of T helper (Th)1-mediated immune responses, with elevated interferon- (IFN-) production and impaired function of regulatory T cells (Tregs), which normally restrain autoreactive lymphocytes [11,12]