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Description
An imbalance between the reactive oxygen species (ROS) production and the bodys detoxification ability cause oxidative stress, damaging cells and tissues and contributing to vascular aging
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In the DPP-4/Diprotin A co-crystal structure (PDB ID 1nu8), the peptide bond between the second and third residues is not cleaved after formation of the tetrahedral intermediate, wherein the sidechain of the catalytic serine (Ser630) is covalently linked to the carbonyl carbon atom Pro2
In those cases, prompt discontinuation and urgent care are essential

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