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However, driven by shifts in dietary patterns and rising obesity rates, its incidence and prevalence are steadily increasing, with the disease increasingly manifesting in younger individuals ( Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are a novel class of antidiabetic agents that activate the GLP-1 receptor to stimulate insulin secretion and inhibit glucagon secretion in a glucose-dependent manner, delay gastric emptying, thereby controlling blood glucose and promoting weight loss ( Previous meta-analyses have primarily pooled the cardiovascular effects of GLP-1 RAs in patients with T2DM ( This study performed a systematic review and meta-analysis to evaluate the effects of subcutaneous vs

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It is contraindicated in patients with a personal or family history of medullary thyroid cancers (MTC) or patients with multiple endocrine neoplasia syndrome type 2 (MEN2).[30] FUTURE INDICATIONS AND TRIALS Oral semaglutide has been explored with higher doses of 25 and 50 mg in ongoing PIONEER plus trials.[39] Another trial under the name PIONEER TEEN is ongoing to see the efficacy and safety of semaglutide in children and teenagers with age 10 years to 17 years.[40] PIONEER REAL is a global prospective, non-interventional single-arm real-world study with oral semaglutide.[41] EVOKE and EVOKE plus are ongoing trials to see the effect of oral semaglutide in Alzheimers disease.[42] SOUL is an ongoing CV superiority trial with an objective to prove CV benefits with this molecule