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It also raises the risk of sarcopenia the age-related loss of muscle mass and function that contributes to frailty, falls, and reduced quality of life

This study, together with a companion manuscript, shows that in mice, weight loss as a result of GIP receptor antagonism requires and potentiates functional GLP-1 receptor signalling in the brain, explaining how both GIP receptor agonists and antagonists trigger weight loss through different mechanisms.

Stricter FDA rules are reshaping GLP-1 access, opinions on regulation, and growing interest in alternatives like liraglutide.