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Safety info: GLP-1 medications are used to treat obesity or overweight (with weight-related problems), along with diet and exercise

GLP-1(28-36)amide is an antioxidant and targets to mitochondrion, inhibits mitochondrial permeability transition (MPT)

However, some patients do report irritability, which is most often related to indirect factors such as under-eating, blood sugar fluctuations, sleep disruption, or changes in reward signaling rather than the medication itself.This post explains the science behind these effects, identifies who may be more vulnerable, and outlines practical strategies clinicians and patients can use to reduce risk