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These effects appear to be mediated through modulation of dopamine signaling in the mesolimbic reward system in animal models, potentially dampening the reinforcing properties of addictive substances

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The regulator went against the recommendation of its Pulmonary-Allergy Drugs Advisory Committee (PADAC), which in May voted 16-6 in favor of the treatment in adults and 17-5 in kids 18 years and younger

This latter volume was used for isolation