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Moreover, 77% of participants achieved a target HbA1c level when treated with once-weekly exenatide compared with 61% of twice-daily exenatide group ( P =0.0039)

The indirect effects, mediated through reductions in HbA1c and body weight, appeared to explain 45.9% [95% CI 20.771.0%] of the decrease in UACR associated with tirzepatide relative to the pooled comparator and driven primarily by improved glycemic control, with no statistically significant role for weight reduction

However, the recent reclassification of certain peptides as biologics may have an effect on semaglutides compounding status