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Verdict at a Glance Retatrutide demonstrated greater weight loss than survodutide in their respective Phase 2 trials (24.2% vs 18.7%), likely driven by its unique triple-agonist mechanism that adds GIP receptor activation
Slows down the rate of food evacuation from the stomach into the small intestine, allowing carbohydrates and other nutrients to enter the intestines gradually to be absorbed, avoiding steep spikes in postprandial blood glucose, and smoothing out the curve of blood glucose fluctuations
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