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Our results suggest that combination therapy leads to a greater reduction in body weight, HbA1c, and FPG compared to SGLT-2i monotherapy
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Furthermore, compared with placebo, liraglutide treatment decreased leptin by 20% and liver fat content by 44%, thus supporting a specific effect on hepatic ectopic fat
INS-1 832/3 were maintained in RPMI-1640 at 11 mM d-glucose, supplemented with 10% fetal bovine serum (FBS), 10 mM HEPES, 2 mM l-glutamine, 1 mM pyruvate, 50 M -mercaptoethanol, and 1% penicillin/streptomycin 21
