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Its action mainly occurs in the intestine, suggesting that intestinal microbiota may be another target of metformin (Wang J

Clinical studies A total of 22 completed clinical studies were identified (Table 1 and Extended Data Tables 1 and 2), with another 8 clinical trials still ongoing (Supplementary Section 3)

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The review addresses the potential for complementary supplements during GLP-1 therapy to support muscle health, nutrition, and overall wellness, including with ingredients such as multivitamins, protein supplements, creatine, HMB, antioxidants, fiber, and probiotics