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Description
At the 12mg/week dose, mean body weight reduction was approximately 24.2% at 48 weeks, placing Retatrutide above semaglutide (~14.9% at 68 weeks, STEP 1) and broadly comparable to or above tirzepatide (~20.9% at 72 weeks, SURMOUNT-1) in historical comparison

CagriSema vs Retatrutide is one of the most important next-generation obesity peptide comparisons going into 2026

Proper Injection Technique for Semaglutide Pens Pinch the skin at your injection site gently between thumb and forefinger to create a small fold

Importantly, weight loss itself provides no benefits to pregnant patients and may cause fetal harm