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47 Visceral fat accumulation in patients with obesity causes a number of changes (oxidative stress, activation of the RAAS and gut dysbiosis), resulting in insulin resistance, increased vascular stiffness, T2D, dyslipidaemia, hypertension, coronary atherosclerosis and, ultimately, HFpEF

In Experiments 1 and 2, we hypothesized that semaglutide pretreatment would disrupt the discriminative stimulus effects of alcohol using acute, repeated, and control (water) test designs in a balanced cohort of male and female rats trained to discriminate alcohol (2 g/kg)

Remember, 1 pound of body weight equals an extra 4 pounds of pressure on your knees while walking

Obes Res Clin Pract 9(3):301304