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Introducing targeted amino acid substitutions to the GLP1 sequence with the aim of increasing helical stability resulted in enhanced cAMP signalling and insulin release, with a lesser effect on arrestin2 recruitment which, although bias was not formally quantified in this study, again suggested that cAMPfavouring GLP1 receptor agonism is preferred for insulin release (Plisson et al., 2016)

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However, too high a dose can also lead to side effects like anxiety or fatigue, which may reduce physical activity and contribute to weight gain

10.1146/annurev-animal-111523-102249 Annu Rev Anim Biosci