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For someone who has struggled for years with intense hunger, constant cravings, or blood sugar instability, that can feel dramatic
In comparison of food intake during an ad libitum buffet meal, treatment with pramlintide resulted in an approximately 200 calorie decrease in food intake compared to placebo administration (430)

Crit Care Med 32 (3): 848-51

While long-term clinical studies are ongoing, we can be carefully optimistic that improved GLP-1-based pharmacology can one day be safely applied to further lower body weight relative to currently available GLP-1R agonists
