soul trial oral semaglutide Reduces CV Events in T2DM β (NEJM, Mar 2025) Relevant for: cardiology, diabetology, nephrology, internal medicine π§ͺ T2DM + ASCVD/CKD π Oral semaglutide 14 mg vs placebo π SOUL trial shows oral semaglutide
Description
Michelle Cardel
In two trials, the effects of prior food ingestion (food effect), post-dose fasting period and water volume with dosing (dosing conditions) on oral semaglutide pharmacokinetics were investigated
Semaglutide slows stomach emptying to reduce appetite, but this mechanism can lead to constipation in many patients
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