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To evaluate the observed response, we measured cAMP from sinus node superfusates collected right before and 15 min after GLP-1 exposure, as well as in supernatants from sinus nodes statically incubated with or without GLP-1 for 30 min

Some studies have demonstrated the ability of gut-derived GLP-1 to cross through the blood-brain barrier and thoroughly perfuse the brain parenchyma, but whether its effects are similar to that of PPG-derived GLP-1 remains to be established [50, 53]

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Indeed, it has been suggested that pancreatic Gcg -encoded peptides are essential components in adaptation to metabolic stress and that a lack of communication within the endocrine pancreas contributes to variations in glucose tolerance [25]