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Nature 490:5560

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In a study involving patients with DM2 who were not responding adequately to metformin, lixisenatide demonstrated the most effective efficacy-to-tolerance ratio at a dose of 20 g administered once daily

However, compared to participants taking dipeptidyl peptidase-4 inhibitors (DPP4is), GLP-1RAs were associated with a slight decrease in depression risk
