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Not only is there a rapid weight gain for most patients, but there is documented re-worsening of comorbidities such as cardiovascular risk factors. The new insurance restrictions have fueled the use of direct-to-consumer programs such as NovoCare and LillyDirect, where prices range from $149 to $449 a month, depending on the drug and dosage

The trade-off between greater efficacy and increased side effect burden is real
