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In contrast, specific to the L-cell, Gcg expression has been shown to be downstream of the canonical Wnt signaling pathway (a specific signaling transduction pathway), -catenin and transcription factor 7 like 2 (TCF7L2) (28)

Extracellular TDP-43 aggregates target MAPK/MAK/MRK overlapping kinase (MOK) and trigger caspase-3/IL-18 signaling in microglia

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