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Sitagliptin was the first agent introduced (in 2006) with other substances having followed soon after

Still, the effects of these naturally occurring extracts are known to be quite mild and not effective enough to treat people who are dealing with intense health issues like obesity

In the case of the PPAR- agonist drugs, the most widely anticipated additional benefit was decreased vascular disease because of favorable effects of the drug class on risk factors for vascular disease supported by murine studies reporting protection against ischemic heart disease (3)

Tirzepatide: Unlike a semaglutide, this peptide is a dual agonist