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Starting in our mid-20s, collagen and elastin begin to break down, causing our skin to wrinkle and lose its elasticity

However, the evidence for retatrutide, ecnoglutide, and mazdutide was rated as low or very low certainty, meaning the estimates could change as stronger studies become available

For those with NAFLD, repeat LFTs at intervals aligned with local protocols (often 36 months) during the first year of treatment can help assess whether metabolic improvements translate into hepatic benefits
