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This might arise early in the pathogenesis of T2DM, as one of many risk factors contributing to the initial onset of hyperglycaemia in susceptible individuals, or later, as a consequence of already existing metabolic changes causing increased DPP-4 activity and further exacerbating the deterioration of glycaemic control

A slight reduction in blood pressure has also been observed in SUSTAIN-6 and LEADER trials [53, 54]

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If you need flexibility in case the program doesnt work out, Hers may feel risky