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Seek medical attention if you experience: Severe or persistent nausea and vomiting that prevents you from eating or drinking adequately, as this may lead to dehydration Severe abdominal pain , particularly if it radiates to the back, as this could indicate pancreatitis a rare but serious side effect of GLP-1 receptor agonists [1] [2] Signs of dehydration , such as dark urine, dizziness, dry mouth, or reduced urination Frequent hypoglycaemia (low blood sugar episodes), especially if you are also taking sulphonylureas or insulin Unexplained weight loss that seems excessive or concerning Visual changes or symptoms of diabetic retinopathy worsening, which should be monitored in patients with existing eye complications [1] [2] Allergic reactions , such as rash, itching, swelling, or difficulty breathing Upper right abdominal pain, fever or yellowing of the skin or eyes , which could indicate gallbladder problems Reduced urine output, swelling or confusion , which might suggest acute kidney injury Call 999 immediately if you experience severe chest pain, a severe allergic reaction (anaphylaxis) with breathing difficulties, or severe sudden abdominal pain with vomiting

If using a pen with replaceable needles, attach a new needle according to the manufacturer's instructions, remove both the outer and inner needle caps, and perform a flow check/priming if required by your specific device

They may need more frequent blood glucose monitoring and adjustment of medications that may cause hypoglycemia (e.g., if pursuing low carbohydrate diets, intermittent fasting, very low carbohydrate/keto diet)

Keep your medication in the original box or container to block light exposure, which can degrade the active ingredients over time